8-Hydroxyeicosapentaenoic Acid Decreases Plasma and Hepatic Triglycerides via Activation of Peroxisome Proliferator-Activated Receptor Alpha in High-Fat Diet-Induced Obese Mice

Table 2

Plasma triglycerides, glucose, total cholesterol, AST, ALT, and hepatic triglyceride in male C57BL/6J-DIO mice fed HFD, HFD with EPA, HFD with 8-HEPE, LFD, LFD with EPA, or LFD with 8-HEPE for 4 wk. Values are means ± SDs, . Labeled means without a common letter differ; . HFD: high-fat diet; LFD: low-fat diet; HEPE: hydroxyeicosapentaenoic acid; EPA: eicosapentaenoic acid.

	Plasma					Hepatic
	Triglyceride (mg/dL)
HFD	91.36 ± 22.14	335.23 ± 59.78	172.04 ± 16.35	30.85 ± 3.59	10.88 ± 2.15	50.18 ± 10.87
HFD with EPA	82.10 ± 23.53	327.58 ± 37.75	168.27 ± 21.07	32.45 ± 6.87	10.86 ± 3.53	44.31 ± 13.79
HFD with 8-HEPE	78.12 ± 18.44	327.05 ± 47.14	166.13 ± 14.38	30.35 ± 3.41	9.30 ± 1.39	40.53 ± 7.65
LFD	74.76 ± 25.10	308.01 ± 28.80	103.07 ± 9.12	31.76 ± 4.24	5.93 ± 1.13	29.27 ± 5.32
LFD with EPA	70.99 ± 44.21	279.73 ± 25.72	109.13 ± 17.21	32.33 ± 6.19	6.73 ± 1.39	28.47 ± 4.92
LFD with 8-HEPE	68.14 ± 23.10	319.66 ± 52.42	107.02 ± 11.98	35.71 ± 7.15	7.72 ± 1.43	30.85 ± 8.52