Sensitivity and Optimal Control Analysis of an Extended SEIR COVID-19 Mathematical Model

<div>Plot of the vaccine reproduction number <svg height="11.927pt" id="M208" style="vertical-align:-3.291101pt" version="1.1" viewbox="-0.0498162 -8.6359 15.2724 11.927" width="15.2724pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M610 18C585 26 567 34 540 68C517 97 499 128 476 171C452 215 425 276 413 304C496 332 570 394 570 494C570 555 545 595 509 619S419 650 364 650H139L133 622C216 615 219 612 203 527L129 132C112 40 105 36 23 28L17 0H279L285 28C199 34 194 40 211 132L239 284H284C320 284 334 275 351 236C374 182 394 140 420 93C459 23 495 -1 592 -8H600L610 18ZM480 485C480 424 449 372 403 342C374 323 338 316 293 316H245L291 562C296 589 301 601 311 608S337 618 358 618C432 618 480 575 480 485Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,8.086,3.132)"><path d="M735 650H491L482 618L516 614C568 608 571 595 541 535L299 115H297L196 559C187 600 195 608 238 614L265 618L275 650H26L18 618C79 611 98 605 115 527L234 -9H272C389 197 542 449 591 523C647 608 656 612 726 618L735 650Z"></path></g></svg> against the rate of vaccination <svg height="12.7178pt" id="M209" style="vertical-align:-3.42947pt" version="1.1" viewbox="-0.0498162 -9.28833 15.6668 12.7178" width="15.6668pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M300 -147C201 -63 143 98 143 270S200 602 300 686L282 710C136 610 70 450 70 271V270C70 89 136 -72 282 -170L300 -147Z"></path></g><g transform="matrix(.013,0,0,-0.013,4.498,0)"><path d="M478 372C478 418 458 448 431 448C409 448 389 431 389 410C389 404 391 400 394 395C398 388 406 371 406 348C406 253 308 122 251 51H249C254 122 249 257 231 336C212 421 189 448 159 448C126 448 75 412 23 327L48 306C83 354 103 371 115 371C125 371 134 360 144 334C185 224 192 64 183 -19C146 -100 116 -202 110 -244L125 -261C154 -259 208 -234 222 -220C222 -194 225 -84 235 -23C247 -3 273 36 308 79C379 165 478 288 478 372Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.014,0)"><path d="M275 270C275 450 212 609 64 710L45 686C145 604 203 442 203 270S147 -63 45 -147L64 -170C213 -68 275 89 275 270Z"></path></g></svg> and vaccine efficacy <span class="nowrap"><svg height="11.5564pt" id="M210" style="vertical-align:-2.26807pt" version="1.1" viewbox="-0.0498162 -9.28833 15.8886 11.5564" width="15.8886pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M300 -147C201 -63 143 98 143 270S200 602 300 686L282 710C136 610 70 450 70 271V270C70 89 136 -72 282 -170L300 -147Z"></path></g><g transform="matrix(.013,0,0,-0.013,4.498,0)"><path d="M501 444C501 643 409 712 321 712C208 712 108 618 108 502C108 412 172 331 293 331C337 331 394 359 420 378C397 154 341 41 258 41C209 41 178 76 178 161C178 232 171 299 114 299C76 299 38 272 23 257L29 232C42 236 54 239 66 239C91 239 106 221 102 149C95 20 158 -12 219 -12C264 -12 314 10 353 47C461 150 501 295 501 444ZM423 443C423 433 422 422 421 412C401 396 370 385 335 385C245 385 180 444 180 537C180 609 212 671 286 671C349 671 423 595 423 443Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.233,0)"><path d="M275 270C275 450 212 609 64 710L45 686C145 604 203 442 203 270S147 -63 45 -147L64 -170C213 -68 275 89 275 270Z"></path></g></svg>.</span></div>

Journal of Mathematics

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Figure 5

Figure 5: Sensitivity and Optimal Control Analysis of an Extended SEIR COVID-19 Mathematical Model 