Mus308 Processes Oxygen and Nitrogen Ethylation DNA Damage in Germ Cells of Drosophila

Table 3

Relative and absolute mutation frequencies (F₁ and F₂ values expressed as mutation frequencies ×10⁻⁵) of the different mutation types constituting the mutation spectra induced by DES in postmeiotic male germ cells, in 𝑚𝑢𝑠308⁻and 𝑚𝑢𝑠308⁺ conditions.

Chemical	Mutation type	mus308 −			mus308 +(a)
		Relative frequency	Absolute frequency (×10^−5)		Relative frequency	Absolute frequency (×10^−5)
		%	F1	F2	%	F1	F2
DES	GC-AT	47.8	0.5	7.9	73.3	6.8	49.0
	AT-GC	17.4	—	5.3	3.3	—	3.3
	AT-TA	17.4	0.5	4.0	10.0	1.9	3.3
	AT-CG	—	—	—	6.7	1.0	3.3
	GC-TA	8.7	—	2.6	—	—	—
	Deletions	8.7	0.5	1.3	6.7	—	6.5

(𝐚)Data of mus308 + conditions are from Sierra et al. [25]. One experiment was carried out mating the treated males to I,v;bw females to check the validity of the previous data for comparisons.