Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand
Figure 3
Scatchard plots of AIC:DNA binding. (a) The curve of AIC binding to G-c-Myc (Pu18) registered by UV absorption (triangles) and spectrofluorimetry (squares). The circles represent absorption of nonfluorescent complexes. (b) The curve of AIC binding to G-tel registered by UV absorption (triangles) and spectrofluorimetry (squares). (c) The curve of AIC binding to Pu18 c-Myc duplex registered by UV absorption. The parameters and were calculated per DNA strand: Hanks’ buffer, °C.
