Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand
Figure 5
CD spectra of G-c-Myc and c-Myc duplex at different AIC concentrations: (a) CD spectra of free G-c-Myc (filled circles) and in complex with 3 AIC molecules (open circles). The concentration of G-c-Myc was 1 μM; the concentrations of AIC corresponded to Hanks’ buffer, °C. (b) CD spectra of Pu18 c-Myc duplex (0.5 μM): free (open circles), in complexes with 3 AIC molecules (filled circles) and in the presence of an excess of AIC (12 molecules; filled squares).
