Review Article

Chemical Approaches for Structure and Function of RNA in Postgenomic Era

Figure 24

The β-elimination of cap core [16]. The cap core (peak b from Figure 23) was treated with NaIO4 and aniline to remove m 3 2 , 2 , 7 G by β-elimination reaction. The remaining nucleotide was chromatographed in the ATP region indicating it is pppAm. This proved that the cap core was m 3 2 , 2 , 7 G p p p A m .
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