Chemical Approaches for Structure and Function of RNA in Postgenomic Era

Figure 34

Crystal structure of hTgs1 [90]. The crystal structure of hTgs1 with substrate m⁷GTP and AdoHcy (at the site for AdoMet). The m⁷G is stacked between tryptophan 766 and serine 671 [90]. (a) Relative orientation of substrates m⁷GTP and AdoHcy at binding pockets. (b) Detailed view of the binding pocket for m⁷GTP (shown W766 and S671). (c) Detailed view of the binding pocket for AdoHcy.

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