Chemical Approaches for Structure and Function of RNA in Postgenomic Era

Figure 6

Stereochemistry of the reaction catalyzed by RNase A [10]. The intermediary 2′,3′ cyclic nucleotide (cNp or cNMP) is hydrolyzed to a 3′ phosphorylated mononucleotide. Other 2′-OH requiring enzymatic and alkaline hydrolysis may go through the same path.