DNAzymes, Novel Therapeutic Agents in Cancer Therapy: A Review of Concepts to Applications

Table 6

Types of DNAzyme delivery systems and the outcomes.

Delivery systems	Outcomes	References
Biodegradable poly(D, L-lactide-co-glycoid) copolymer (PLGA) microspheres	Efficient and sustained delivery	[146]
Cyclodextrin-containing polycation (CDP)	A rapid and efficient intracellular uptake into various cell lines	[147]
Branched polyethylenimine	Higher biocompatibility and efficient transfection. Less cytotoxicity and promote gene dissociation	[148]
N-Acetyl-L-leucine-polyethylenimine (N-Ac-L-Leu-PEI)	Efficient cellular uptake and exhibited protective function against nucleases	[79]
Dendrimers	Low toxicity, higher water solubility, and increased stability against hydrolysis	[149]
Modified fourth-generation dendrimers termed G4 (MeI)	Efficient DNAzyme delivery without substantial toxicity	[149]
Colloidal gold nanoparticles	Less toxic and an efficient DNAzyme transfection	[150]
Liposomes	Efficient targeted delivery	[151–153]
Chitosan nanoparticles	Effective cellular uptake ability, remain stable at room temperature for a month and for seven days in serum without a substantial loss in activity	[154–156]
	Toxic side effects such as myelosuppression, alopecia, and hepatic toxicity can be associated	[157]