Synthesis and Evaluation of MGB Polyamide-Oligonucleotide Conjugates as Gene Expression Control Compounds
Scheme 2
Synthesis of aminoalkyl linker reagents. Reagents and conditions: i H2N(CH2)nNH2, MeOH, rt; (ii) pyridinium hydrochloride, 8 (20%); 10 (61%); 11 (45%). Compound 9 was prepared as previously described [10–13].
