Synthesis and Evaluation of MGB Polyamide-Oligonucleotide Conjugates as Gene Expression Control Compounds

Scheme 3

Synthesis of pyrrole polyamides bearing aminoalkyl linker. Reagents and conditions: i 1 M NaOH aq./MeOH, 60°C; Dowex 50WX8 (H⁺-form); ii 9, 10, or 11, DCC, HOBt, DIEA, DMF, and rt; 13 (71%); 14 (84%); 15 (61%). Compound 12 was prepared as previously described [10–13].