Application of Response Surface Methodology for Optimization of Paracetamol Particles Formation by RESS Method

Table 2

Box-Behnken experimental design with the observed response.

Run	𝑥1	𝑥2	𝑥3	𝑥4	Extraction temperature (K)	Extraction pressure (MPa)	Preexpansion temperature (K)	Postexpansion temperature (K)	Average particle size (μm)
1	0	1	0	1	333	18	383	323	0.136
2	−1	0	0	1	313	14	383	323	0.301
3	1	−1	0	0	353	10	383	298	0.164
4	0	1	1	0	333	18	403	298	0.407
5	0	−1	0	1	333	10	383	323	0.236
6	0	1	0	−1	333	18	383	273	0.663
7	0	1	−1	0	333	18	363	298	0.748
8	−1	0	1	0	313	14	403	298	0.588
9	0	−1	−1	0	333	10	363	298	0.25
10	0	−1	0	−1	333	10	383	273	0.745
11	−1	0	0	−1	313	14	383	273	0.867
12	−1	−1	0	0	313	10	383	298	0.307
13	0	0	−1	1	333	14	363	323	0.231
14	−1	1	0	0	313	18	383	298	0.855
15	1	0	1	0	353	14	403	298	0.417
16	0	0	0	0	333	14	383	298	0.496
17	0	−1	1	0	333	10	403	298	0.218
18	1	0	0	1	353	14	383	323	0.147
19	−1	0	−1	0	313	14	363	298	0.503
20	1	1	0	0	353	18	383	298	0.305
21	0	0	1	1	333	14	403	323	0.187
22	1	0	0	−1	353	14	383	273	0.685
23	1	0	−1	0	353	14	363	298	0.45
24	0	0	1	−1	333	14	403	273	0.777
25	0	0	−1	−1	333	14	363	273	0.827