Evaluation on Cartilage Morphology after Intra-Articular Injection of Titanium Dioxide Nanoparticles in Rats
Figure 10
The ultrastructure of articular cartilage in the distal femur exposed to TiO2 nanoparticles. N: nucleaus; ER: endoplasmic reticulum; M: mitochondria. After TiO2 nanoparticles exposure, the chromatin was condensed and distributed over the fringe of nucleus, the nuclear membrane was invaginated, the endoplasmic reticulum was dilated, and the ribosomes were decreased in chondrocyte at postexposure day 1. At day 7, a lamellar arrangement for rough endoplasmic reticulum was observed in cytoplasm. At day 14, the intense axons on the cell surface were developed and the mitochondria were rich and became swollen in chondrocyte. At day 30, the endoplasmic reticulum ruptured, and the fragments were distributed in cytoplasm.
