Fabrication of Novel Biodegradable α-Tricalcium Phosphate Cement Set by Chelating Capability of Inositol Phosphate and Its Biocompatibility

Figure 10

Histological sections showing IP6-α-TCP120 (P/L = 1/0.40 [g/cm³]) cement specimens implanted into the rabbit tibia. (a)–(f): undecalcified sections stained with HE; (g)–(i): decalcified sections stained with TRAP. (a), (d), and (g): 4 weeks of implantation; (b), (e), and (h): 8 weeks of implantation; (c), (f), and (i): 24 weeks of implantation. The low-magnification images (a)–(c) showed the entire cement specimen (C), and (d)–(f) presented high-magnification images of the dotted square areas shown in (a)–(c), respectively, where the newly formed bones were evident by light pink staining. The arrows in (d)–(f) indicated aligning osteoblast-like cells forming the newly formed bones (N). The asterisks (*) in (g)–(i) represented TRAP-positive osteoclast-like cells resorbing the cement.