Combining Hyaluronic Acid with Chitosan Enhances Gene Delivery

Figure 3

Polyplexes encapsulation efficiency and nuclease protection analyzed by 1% agarose gel electrophoresis, DNA visualized with ethidium bromide, (a) and (b) pDNA encapsulation in CSpDNA and CSHApDNA polyplexes, respectively, and lanes positive for polyplexes but negative for pDNA represent unloaded polyplexes. DNA is protected against DNase I digestion: (c) CSpDNA and (d) CSHApDNA polyplexes after incubation with DNase I.

(a)

(b)

(c)

(d)