Combining Hyaluronic Acid with Chitosan Enhances Gene Delivery

Figure 5

Polyplexes remain stable at physiological conditions, (a) CSpDNA and (b) CSHApDNA polyplexes after incubation in PBS or DMEM with 10% FBS at 37°C. Polyplex pDNA retention analyzed by 1% agarose gel electrophoresis and pDNA visualized with ethidium bromide (P-polyplexes, P+DNase-polyplexes incubated with DNase I, data shown only for CSHA8 but representative of all CSHA polyplexes).

(a)

(b)