Penetration and Silencing Activity of VEGF Dicer Substrate siRNA Vectorized by Chitosan Nanoparticles in Monolayer Culture and a Solid Tumor Model In Vitro for Potential Application in Tumor Therapy

Table 1

Particle size, PDI, and zeta potential of DsiRNA-CS nanoparticles prepared at different CS concentrations, .

CS concentration (% w/v)	Particle size (nm) ± SD	PDI ± SD	Zeta potential (mV) ± SD
0.1	126.37 ± 15.52	0.30 ± 0.05	+30.50 ± 2.55
0.2	180.00 ± 18.78	0.35 ± 0.18	+37.13 ± 2.01
0.3	230.23 ± 13.80	0.40 ± 0.05	+40.27 ± 4.07
0.4	336.50 ± 11.38	0.55 ± 0.02	+55.30 ± 3.91

SD, standard deviation; , sample number.