Size-Dependent Cytotoxicity and Genotoxicity of Silver Nanoparticles in Cochlear Cells In Vitro

Figure 10

The DNA lesion scores (comet assay) after 4 h exposure to AgNPs were significantly higher in HEI-OC1 cells compared to HaCaT, for all the sizes of the NPs, the difference being significant for the 5 nm NPs (, two-way ANOVA, Bonferroni posttest). In both cell lines, the most significant DNA lesions were induced by the 5 nm NPs, followed by the 25 nm, 50 nm, and 110 nm NPs.