Size-Dependent Cytotoxicity and Genotoxicity of Silver Nanoparticles in Cochlear Cells In Vitro

Figure 6

Ultrastructure of HEI-OC1 cells incubated for 24 h with the AgNPs with diameters of 5 nm (a), 25 nm (b), 50 nm (c), and 110 nm (d). The AgNPs are visible as clusters in the endosomes (en) and in the cytoplasm, both next to the plasma membrane (pm) and nucleus (n). The 5 nm AgNPs are also visible inside the nucleus (n). In the lysosomes (ly), the smaller NPs were observed as clusters (a, b) while the larger NPs were relatively dispersed (c, d). ce—centriole, nu—nucleolus, rer—rough endoplasmic reticulum.

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