Size-Dependent Cytotoxicity and Genotoxicity of Silver Nanoparticles in Cochlear Cells In Vitro

Table 3

AgNPs induced DNA lesion size dependently: the 5 nm NPs induced the most important DNA lesions in both cell lines, followed by the 25 nm, 50 nm, and 110 nm NPs.

Lesion score treated cells vs. control
AgNP	HaCaT		HEI-OC1
	2 h	4 h	2 h	4 h
5 nm	↑ 1.53x	↑ 1.98x	↑ 3.77x	↑ 4.07x
25 nm	↑ 1.18x	↑ 1.45x	↑ 2.44x	↑ 2.7x
50 nm	↑ 1.19x	↑ 1.38x	↑2.1x	↑2.62x
110 nm	↑ 1.7x	→	↑2.24x	↑2.39x

↑-fold increase; →-no change.