A Unique Protein Self-Assembling Nanoparticle with Significant Advantages in Vaccine Development and Production

Figure 2

Conceptualized NSP10 particle symmetry The symmetry and fusion polarity of NSP10 as depicted by a tetrahedron. The example shown is illustrative of the NSP10 HVS gD nanoparticle discussed in the following sections where gD shown in blue and His-tag, shown in red, are fused through N-terminus and C-terminus, respectively. Here, the threefold sets of the NSP10 N-termini are shown at each pyramid apex with the corresponding C-termini fused His-tags shown in red emanating from each of the threefold axes centered on each lateral face. Arrows denote the direction of the polypeptide chain from the N- to the C-termini.