Galactosamine-Conjugating Zwitterionic Block Copolymer for Reduction-Responsive Release and Active Targeted Delivery of Doxorubicin to Hepatic Carcinoma Cells

Scheme 2

Synthesis route of GAL-m-polymer. (i) CDI, anhydrous DCM, RT., 24 h; (ii) DMSO, pyridine, TEA, RT, 48 h; (iii) DCC, NHS, RT., 48 h; (iv) AIBN, THF, saturated salt water, 60°C, 48 h; (V) EDC·HCl, NHS, DMSO, water, RT.