Nanomaterial-Based Prosthetic Limbs for Disability Mobility Assistance: A Review of Recent Advances

Tan, Qiaoyin; Wu, Cuicui; Li, Lei; Shao, Weide; Luo, Min

doi:https://doi.org/10.1155/2022/3425297

Journal of Nanomaterials

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Advanced Nanotechnology for Biomedical and Healthcare Applications

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Review Article | Open Access

Volume 2022 | Article ID 3425297 | https://doi.org/10.1155/2022/3425297

Nanomaterial-Based Prosthetic Limbs for Disability Mobility Assistance: A Review of Recent Advances

Qiaoyin Tan,¹Cuicui Wu,²Lei Li,²Weide Shao,²and Min Luo^3,4

Academic Editor: Weiguo Li

Received24 Feb 2022

Revised08 Mar 2022

Accepted09 Mar 2022

Published31 Mar 2022

Abstract

The emergence of new hybrid nanomaterial has enabled prosthetic devices to have more performance and significantly improved the quality of life of the disabled. Due to the biosensing properties of prosthetic limbs made of nanomaterials, a large number of nanocomposites have been designed, developed, and evaluated for various prosthetic limbs, such as e-skin, e-skin’s neurotactility sensing, human prosthetic interface tissue engineering, bones, and biosensors. Nano-based materials are also considered to be the new generation of scientific and technological materials for the preparation of various prosthetic devices for the disabled, which can effectively improve the sense of use of the disabled and achieve functional diversity. The study described various nanomaterials for prosthetic devices, and introduced some basic components of nanocomposites; their applications are in three areas, such as bone, skin, and nerve, and evaluated and summarized the advantages of these applications. The results show that (1) carbon-based nanomaterials as neural materials have been studied most deeply. Due to that strong stability of the carbon-based material and the simple transmission mechanism, the cost can be controlled in manufacturing the artificial limb. Materials with human-computer interaction function are the research focus in the future. (2) Skin nanomaterials are mainly composite materials, generally containing metal- and carbon-based materials. Ionic gels, ionic liquids, hydrogels, and elastomers have become the focus of attention due to the sensitivity, multimodal, and memory properties of their materials. (3) Outstanding nanomaterials for bone are fibrous materials, metallic synthetic materials, and composite materials, with extremely high hardness, weight, and toughness. Of the skeletal materials, the choice of prosthetic socket material is the most important and is typically based on fiber laminate composites. Some of these materials make sensors for durability and performance that can be used for large-scale clinical testing.

1. Introduction

Since the emergence of nanotechnology, the application of nanomaterials in wearing aids and sports prosthetic limbs has been the focus of attention of researchers in the field of disability sports. As nanomaterials have different electrical, magnetic, thermal, mechanical, and other properties from common materials, they are currently used by a large number of scholars in the field of prosthesis manufacturing [1]. Prosthetic limbs used by persons with disabilities to assist movement include mechanical prosthetic limbs (ordinary materials), electric prosthetic limbs (nanomaterials), and myoelectric prosthetic limbs (nanomaterials). According to research, artificial limbs made of traditional materials are stiff, expensive, and not easy to handle [2]. The users of artificial limbs made of traditional materials can only rely on the uncomfortable tactile information between the residual limb and the ground. As a result, the risk of falling is increased, and the activity ability is limited. Artificial limbs are considered to increase cognitive burden of the brain caused by foreign objects in the movement. As a result, many psychological troubles and problems of giving up artificial limbs have become the major causes of burden [3]. The combination of biomedicine and material science has led to the emergence of new hybrid nanomaterials that meet the needs of ideal prosthetic limbs. Prosthetic limbs made of nanomaterials can significantly improve the quality of life of the disabled due to their unique and more capabilities.

Due to the biosensing nature of prosthetic limbs made of nanomaterials, there are different components based on the use of polymer nanocomposites in prosthetic limbs. In these components, the functional stretchable composite structures are mainly manufactured by using conductive nanofillers in an insulating or conductive polymer matrix [4]. Conductive polymers such as carbon-based composites and structures include carbon black (CB), carbon nanotubes (CNT), carbon fibers, graphene sheets, and graphene oxides. Other conductive fillers such as metal nanowires, nanoparticles, ionic liquids, and Mxenes are also quite common. In addition, polymers such as polydimethylsiloxane (PDMS), polyurethane (PU), thermoplastic polyurethane (TPU), ecoflex, polyimide (PI), natural rubber, polypropylene, polypyrrole, and polyethylene terephthalate can be used as materials in the flexible matrix to maintain the nanofiller interface. Conductive polymers, such as poly (3, 4-ethylenedioxythiophene):poly (styrene sulfonate) (PEDOT:PSS) and polyaniline, are also used in functional nanocomposite to support conductive networks [5]. In summary, in functional nanocomposites, the nanofillers impart functional sensing properties, while the polymer matrix supports a conductive network configuration. Some of these materials make sensors for durability and performance that can be used for large-scale clinical testing [6].

In recent years, a large number of nanocomposites have been designed, developed, and evaluated for various prosthetic prostheses, such as e-skin, e-skin’s neurotactility sensing, human prosthetic interface tissue engineering, bones, and biosensors. Nano-based materials are also considered to be the new generation of scientific and technological materials for the preparation of various prosthetic devices for the disabled, which can effectively improve the sense of use of the disabled and achieve functional diversity. Prosthetic limbs made of nanocomposites enable patients to engage in more demanding recreational activities such as running [7]. Today, the use of most nanomaterials holds promise for a variety of prosthetic applications. The study described various nanomaterials for prosthetic devices and introduced some basic components of nanocomposites; their applications are in three areas, such as bone, skin, and nerve, and evaluated and summarized the advantages of these applications.

2. Classification and Application of Tissue Material

2.1. Neural Material

As shown in Table 1, nanomaterials used to manufacture prosthetic nerve sensors are carbon-based materials, metal nanomaterials, metal-polymer mixtures, hydrogels, and the like [8]. As shown in Table 1, carbon-based nanomaterials perform well in creep resistance, and nanoparticle-reinforced composites creep more easily than carbon nanoparticle materials, affecting the useful life of prosthetic limbs [9]. Bionic electronic exogenous nerve sensor can achieve monitor physiological indexes [10] and feel the body movements; the role of the transmission of electrophysiological signals [11], such as additional wearable devices, body temperature, respiratory rate, heart rate, and blood pressure, can also be tested [12]. The neural sensor can be applied to the surface layer of the skin and can also be used for nerve signal transmission inside limbs. When used for the nerve signal transmission of the skin’s surface layer, the carbon nanotube polyester thread of the carbon-based material is highly stretchable and insensitive to deformation, and has excellent stability (> 15,000 cycles test), rapid response (≤ 15 ms), high robustness, geometric layered sensing, and personalized cuttability [13]. In addition, there are 3D graphene-based piezoresistive sensors, which show good performance in electronic skin. It comes from electrospinning and 3D printing because of its simple preparation and readout. It is considered as a promising flexible sensor due to its simple mechanism, low power consumption, and convenient signal acquisition [14].

The neural sensor can also use metal nanomaterial, such as NiCo nanoparticles (as shown in Figure 1), which are derived from that nickel-cobalt nanoparticles obtained on the functionalized multiwall carbon nanotubes by a chemical reduction method and have higher stability, high sensitivity, repeatability, and low detection limit [15]. In terms of the combination of metal polymers and carbon nanomaterials, the polymer part can adjust the metal modulus, and the material can reduce the difference between soft tissues and electrodes and improve the function of prosthetic limbs. In addition, the emerging hydrogel material is also one of the nerve manufacturing options. As an artificial tissue or artificial limb into which bioelectronics can be implanted, it possesses biocompatibility, biodegradability, and antibacterial property. It also protects against heat and freezing and takes a long time to recover. Tensile, compressive, dynamic durability, and strain sensitivity are stronger than other materials [16]. For example, the proanthocyanidin/reduced graphene oxide (PC/rGO) composite material with a neural-like nanonetwork is introduced into a glycerol-plasticized polyvinyl alcohol-borax (PVA-borax) hydrogel system to obtain a bionic tactile PC/rGO/PVA hydrogel [17]. It can simulate and control some real epidermal movements controlled by nerves, such as finger bending and facial expression changes, and can simulate the tactile ability through the layered design of hydrogel networks. There is also an ion gel gate organic synaptic transistor (IGOST) which can convert biological signals and bet regulate synaptic attenuation to generate an artificial neural network with long-term memory, thus realizing multifunctional neural mimicry application from neural mimicry calculation to neural prosthesis [18].

2.2. Skin Material

As shown in Table 2, nanomaterials for skin are metal materials, carbon-based materials, and other composite materials [5], in general, to make prosthetic limbs more realistic to the touch; air bladders are designed for each nanomaterial layer on the skin surface [19]. Metallic materials generally have advantages in terms of physical flexibility and sensitivity. Cross-linked gold nanoparticles, such as prosthetic skin and using inkjet printing and microforming techniques, can be extended to submillimeter dimensions [20]. Demonstrating high sensitivity, fast response time, and repeatability, in addition to the former, polydimethylsiloxane (PDMS) zinc oxide (ZnO) nanorods also have the ability to measure temperature [21], as shown in Figure 2. The mechanical feel range of smart sensors made of silver nanowire composites can be significantly enhanced > 100% programmatically, translating actual fingertip events into visual or auditory interactive feedback from the electronic device [22]; can be used for designing the intelligent artificial limbs with sensory disability and physical disability; and shows the feasibility and practicability of the design concept with the sense of future science fiction [23].

The research on carbon-based materials is quite extensive and advantageous. Carbon materials (carbon black (CB), carbon nanotubes (CNT), carbon fibers, graphene sheets, and graphene oxides) are generally made of conductive nanofillers. In multimode sensing, carbon-based materials have attracted much attention due to their strong sensing ability, durability, and low cost [24]. Synthetic materials such as carbon nanotube (CNT) films and polyacrylonitrile (PAN) are very strong, flexible, and stretchable when used as skin. It can withstand more than 1000 cycles with little effect on the output signal [25]. CNT can also be used with thermoelectric clay made of nonionic surfactant as viscous additive to make skin-adaptive thermoelectric patch for e-skin. It serves as a mechanically durable, skin-compatible, semipermanent power source that prevents hammering and even puncture [26].

Carbon-based nanomaterials are made with films of other materials and have different effects. For example, laser-induced graphene (LIG) was prepared by one-step carbonization of polyimide film [27]. Cellular electronic skin can be made that exhibits strain sensitivity to a wide range of tensile and compressive stimuli. Based on its excellent mechanical properties and high staining sensitivity, this e-skin well demonstrates the perception of a wide range of human activities and subtle tactile sensations. There is also a vertical graphene array (VGA), which is directly fabricated on the surface of a natural latex film using a simple method. It can realize the multifunctional tactile sensation to the pressure, air flow, and surface morphology of the object and can also sense the temperature difference sensing characteristic between the detected object and the electronic skin in a noncontact mode, including ultrafast response (6.7 ms) and elasticity (13.4 ms), wide pressure sensing range (2.5 Pa-1.1 MPa), high sensitivity, and strong cyclicity [28].

With respect to other composite materials, ionic gels, ionic liquids, hydrogels, and elastomers, ITS can mimic human skin, including not only typical anisotropic structures, mechanical behaviors, and tactile functions, but even mechanically sensitive ion channels crucial for human tactile sensation. Breakthrough element advances have been made in the sensitivity, response speed, and multimodal sensing of these materials [29], especially electrochromic breakthrough. Also improved carrageenan and locust bean gum are obtained on an elastic matrix by photo-crosslinking with acrylamide, the hydrogel having high elasticity, a stress of 0.04 MPa at 650% strain, which immediately recovers after stretching to 500%, or compression to 10% of its original length, which still maintains its flexibility and conductivity at a low temperature of -10°C [30]. Cutaneous nerve sensing: HCl-doped poly (o-toluidine) (POMANI)-Mn₃O₄ film nanocomposite material can be used for manufacturing conformal temperature sensors for upper limb hand skin or gloves [31]. In the aspect of receptor fabrication for finer functions, there are novel microstructures that introduce folded nanoclusters, semi-ellipsoids, and folds in different sensors to provide more complete and accurate interactive information to achieve finer functions, such as object manipulation and fine tactile discrimination, and real-time recording and mapping of multiple mechanical stimuli [32]. With respect to prosthetic nails, silane and keratin derivatives can mimic a coating of a human nail component, showing resistance to degradation [33].

2.3. Bone Material

As shown in Table 3, the skeletal material of the prosthetic limb is generally used for support and is therefore required to be particularly rigid. However, due to the need for user experience and the need for light weight, bone nanomaterials used for prosthetic limbs include fiber materials, metal composites, and composites. Fiber materials are generally synthesized by adding natural fibers and other fibers, which can significantly enhance their original properties. They are called reinforced materials. Such as a synthetic fiber made of carbon fiber, Kevlar fiber, and glass fiber, after adding a lot of jute fiber, strength and hardness increase with the increase in the proportion of natural fiber and also get higher tensile and bending ability [34]. This fibrous material is commonly used in prosthetic sockets, which are devices that connect prosthetic limbs to amputated parts. Among the skeletal materials, the choice of prosthetic socket material is of prime importance because it determines the user’s experience. The bending strength, maximum shear stress, impact strength, and fracture toughness of the prosthetic socket can be enhanced with different laminated composites (fiber reinforced polymers). Agave fibers have biodegradability, sufficient strength and power, and good mechanical resistance [35], which are generally used as prosthetic engineering components, making prosthetic socket. Fiber-reinforced polyester resin, such as carbon, jute, glass, and perlon, can make prosthetic socket wear more comfortable, light weight, high strength, and durable [36]. Fiber laminate composites are very durable and are reinforced with polyester resin as the bonding matrix and with (jute, glass, carbon, pearl cotton) fibers by vacuum bagging. Upon mechanical stretching, the smoothness of its cross section automatically changes from brittle to semiductile [37].

Prosthetic sockets have cheaper options, such as MWCNT–(polydimethylsiloxane) PDMS, as a composite material that can be used to make prosthetic socket pads for embedded tensile sensors, active cooling systems, and at lower cost [38]. Composites for bones are high-density polyethylene (HDPE), polyamide (PA) 6 or nylon 6, and polyamide (PA) 66, which are the best choice considering standard loads for standing, walking, and running [39].

The metallic material is generally a Ti-Ta composite, sintered at 1200°C, and then hot rolled at a height of 60% reduction, which exhibits a multiscale-layered microstructure [40], as shown in Figure 3. It has a good bearing application prospect in orthopedics, such as EBM Ti-6Al-4V [41]; Ti-Ta composites with bionic structure have high strength, good ductility, low modulus, and good biocompatibility. Other high hardness bone materials include Al₂O₃-CaO composite nanoparticles, which can also significantly improve the tensile properties, flexural properties, and hardness [42].

3. Conclusion

The realization of the vast functions of the intelligent limb cannot be separated from various nanomaterials. When manufacturing an intelligent prosthetic limb, the selection of materials for each part is crucial. The results have shown that (1) carbon-based nanomaterials have been studied most deeply when they are used for neural materials. Because carbon-based material has strong stability and has simple transmission mechanism, the cost can be controlled when being use for manufacturing the artificial limb. Materials with the function of man-machine interaction are the focus of future research. (2) The nanomaterials for skin are mainly composite materials and generally contain metal- and carbon-based materials. Ionic gels, ionic liquids, hydrogels, and elastomers have been the focus of attention due to the sensitivity, multimodal, and memory properties of the materials. (3) Outstanding nanomaterials for bones are fiber materials, metal synthetic materials, and composite materials, with extremely high hardness, weight, and toughness. Of the skeletal materials, the choice of prosthetic socket material is the most important and is generally dominated by fiber laminate composites.

To date, the use of most nanomaterials in the manufacture of prosthetic limbs has been derived from limited experimentation. Due to the extraction process, manufacturing cost, stability, and other reasons, some parts have not yet been put into the actual production of prosthetic limbs. Therefore, the industry needs more relevant research, including specific material update iterations, generation of new functions (not only at the theoretical level), and disability motor function recovery data to finally verify the effectiveness and practicability of these nanomaterials. It is hoped that in the future, more materials can be applied to nanomaterials for artificial limbs, and the nanomaterials are more practical, environment-friendly, and cost-effective.

Conflicts of Interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Authors’ Contributions

The manuscript was written through the contributions of all authors. All authors have read and agreed to the published version of the manuscript.

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