Codelivery of Doxycycline and Hydroxychloroquine to Treatment of Brucellosis: An Animal Study

Table 1

Comparison of biochemical parameter between different treatment groups in acute and chronic brucellosis.

Group/parameter	Stage of disease	AST^1 (U/L)	ALT^2 (U/L)	ALP^3 (U/L)	TBil^4 (mg/dL)	Urea (mg/dL)	Cr^5 (mg/dL)
Positive control	Acute
	Chronic
Free DOX	Acute
	Chronic
Free HCQ	Acute
	Chronic
Free DOX & HCQ	Acute
	Chronic
DOX-SLN	Acute
	Chronic
HCQ-SLN	Acute
	Chronic
DOX-SLN-HCQ	Acute
	Chronic
Healthy rat	Acute
	Chronic

1: aspartate transaminase; 2: alanine transaminase; 3: alkaline phosphatase; 4: total bilirubin; 5: creatinine. Results are represented as the . , significantly compared to the positive control.