Calcium Phosphorus Nanoparticles Coloaded with Paclitaxel and ADAM-10-siRNA for the Treatment of Triple Negative Breast Cancer

Figure 2

Cell uptake and therapy effect to MDA-MB-231 cells in vitro. (a) Cell uptake of CaP-Cy5-siRNA NPs by MDA-MB-231 cells evaluated by CLSM. (b) Cell viability of MDA-MB-231 treated by PBS, PTX, CaP-PTX/siNC NPs, and CaP-PTX/siADAM10 NP analysis of by CCK-8 for 72 h. (c, d) Expression of bcl-2 (c) and bax (d) level was detected by western blot. (e) Quantity analysis of (c). (f) Quantity analysis of (d). (g) ADAM10 expression level was evaluated by RT-qPCR. Scale bar, 50 μm. Data as (, , ).

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