Study on Central Composite Design Method to Optimize the Preparation Process of Chrysophanol-Pluronic F127 Nanomicelles and Pharmacokinetics

Table 1

The table of optimization prescription by CCD design method.

Std	Run	Factor 1 A:A; The ratio of drug dose to excipient dose	Factor 2 B:B; Amount of organic solvent	Response 1 R1; EE%
9	1	15	8	73
4	2	20	10	47.67
12	3	15	8	73
8	4	15	10.8284	34.15
10	5	15	8	73
11	6	15	8	73
3	7	10	10	35.76
5	8	7.92893	8	46.58
13	9	15	8	73
1	10	10	6	49.92
6	11	22.0711	8	53.97
2	12	20	6	68.62
7	13	15	5.17157	78.54