Study on Central Composite Design Method to Optimize the Preparation Process of Chrysophanol-Pluronic F127 Nanomicelles and Pharmacokinetics

Table 2

Model significance results of optimization prescription by CCD design method.

Source	Sum of squares	df	Mean square	-value	value
Model	2826.57	5	565.31	24.37	0.0003	Significant
A-A	210.75	1	210.75	9.09	0.0195
B-B	1197.73	1	1197.73	51.64	0.0002
AB	11.53	1	11.53	0.4969	0.5036
A^2	1012.94	1	1012.94	43.67	0.0003
B^2	567.48	1	567.48	24.47	0.0017
Residual	162.36	7	23.19
Lack of fit	162.36	3	54.12
Pure error	0.0000	4	0.0000
Cor total	2988.93	12