miR-622 Induces Breast Cancer Cell MCF-7 Proliferation, Migration, and Invasion by Directly Negatively Targeting EYA1

Figure 2

Overexpression of miR-622 could promote breast cancer cell proliferation, migration, and invasion. (a) After transfection of miR-622 mimic, the relative expression level of miR-622 in the miR-622 mimic group was higher than that in the miR-NC and control group (miR-622 mimic vs. miR-NC, ; miR-622 mimic vs. control group, ). (b) After transfection of miR-622 mimic for 24 hours, the proliferation of the miR-622 mimic group was stronger than that of the miR-NC and control group (miR-622 mimic vs. miR-NC, ; miR-622 mimic vs. control group, ). (c, d) The mobility in the miR-622 mimic group () was higher than that in the miR-NC group () and the control group () (miR-622 mimic vs. miR-NC, ; miR-622 mimic vs. control group, ). (e, f) The number of invasive cells in the miR-NC and control group was lower than that in the miR-622 mimic group (miR-622 mimic vs. miR-NC, ; miR-622 mimic vs. control group, ).

(a)

(b)

(c)

(d)

(e)

(f)