Research Article
Calotropis gigantea Assisted Synthesis of Zinc Oxide Nanoparticle Catalysis: Synthesis of Novel 3-Amino Thymoquinone Connected 1,4-Dihyropyridine Derivatives and Their Cytotoxic Activity
Table 2
Cytotoxic activity of synthesized compounds (1a-1j) (μM).
| | Cpds | HepG2 | MCF-7 | Hela (Cervical) | | GI50 (μm) | TGI (μm) | LC50 (μm) | GI50 (μm) | TGI (μm) | LC50 (μm) | GI50 (μm) | TGI (μm) | LC50 (μm) |
| | 1a | 33.2 | 18.3 | >100 | — | — | >100 | — | — | 100 | | 1b | 22.2 | 13.1 | 36.8 | 26.1 | 25.1 | >100 | 61.0 | 79.2 | >100 | | 1c | 26.3 | 15.3 | 29.9 | 34.9 | 33.7 | 29.4 | 51.3 | 77.2 | 66.7 | | 1d | 01.0 | 0.25 | 14.0 | 0.89 | 09.3 | 25.0 | 08.9 | 16.8 | 55.9 | | 1e | 25.9 | 28.2 | 12.8 | 34.4 | 19.3 | 26.3 | 44.2 | 62.1 | >100 | | 1f | 19.1 | 0.88 | 0.50 | 28.6 | 11.8 | 0.64 | 31.6 | 44.7 | 0.52 | | 1g | 1.10 | 1.52 | 0.90 | 24.0 | 57.4 | 1.18 | 47.9 | 41.9 | 0.93 | | 1h | 11.3 | 1.08 | 10.0 | 22.9 | 55.3 | 0.95 | 62.9 | 71.3 | >100 | | 1i | 19.3 | 1.35 | >100 | 55.6 | 66.0 | 9.30 | 59.0 | 59.3 | 65.0 | | 1j | 10.3 | 15.3 | 16.8 | 16.0 | 39.3 | 18.0 | 3.3 | 48.3 | 58.3 | | Doxorubicin (standard) | 0.01 | 0.13 | 0.58 | 0.02 | 0.21 | 0.74 | 0.05 | 0.41 | 0.88 |
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