Journal of Nutrition and Metabolism

Review Article

Zinc Transporters, Mechanisms of Action and Therapeutic Utility: Implications for Type 2 Diabetes Mellitus

Table 1

Zinc transporters, cellular location, tissue-specific expression, and disease associations.
Zinc transporterCellular localizationTissue expressionDisease associationsReferences
SLC39A1/ZIP1Plasma membraneUbiquitously expressedProstate cancer[59–61]
SLC39A2/ZIP2Plasma membraneBlood, prostateCarotid artery disease[62–64]
SLC39A3/ZIP3Plasma membrane, intracellular compartmentsMammary gland, prostateUnknown[60, 65]
SLC39A4/ZIP4Apical membranesSmall intestine, stomach, colon, kidney, brainPancreatic cancer, acrodermatitis enteropathica (AE)[62, 66, 67]
SLC39A5/ZIP5Basolateral membranesPancreas, kidney, liver, spleen, colon, stomachUnknown[68, 69]
SLC39A6/ZIP6Plasma membraneUbiquitously expressedBreast cancer[70]
SLC39A7/ZIP7Golgi apparatus, endoplasmic reticulumUbiquitously expressedBreast cancer[71, 72]
SLC39A8/ZIP8VesiclesUbiquitously expressedUnknown[73, 74]
SLC39A9/ZIP9Trans-Golgi networkUbiquitously expressedUnknown[75]
SLC39A10/ZIP10Plasma membraneUbiquitously expressedBreast cancer[76, 77]
SLC39A11/ZIP11UnknownMammary glandUnknown[78]
SLC39A12/ZIP12UnknownRetina, brain, testis, lungSchizophrenia[79]
SLC39A13/ZIP13Golgi apparatusUbiquitously expressedEhlers-Danlos syndrome[80, 81]
SLC39A14/Zip14Plasma membraneUbiquitously expressedAsthma[82, 83]
SLC30A1/ZnT1Plasma membraneUbiquitously expressedAlzheimer's disease, Pancreatic cancer[19, 25, 49]
SLC30A2/ZnT2Vesicles, lysosomesPancreas, kidney, testis, epithelial cells, small intestineUnknown[84]
SLC30A3/ZnT3Synaptic vesiclesBrain, testisAlzheimer's disease[85, 86]
SLC30A4/ZnT4Intracellular compartmentsMammary gland, brain, small intestine, placenta, blood, epithelial cellsAlzheimer's disease[25, 87]
SLC30A5/ZnT5Secretory vesicles, Golgi apparatusUbiquitously expressedOsteopenia[53, 88]
SLC30A6/ZnT6Secretory vesicles, Golgi apparatusSmall intestine, liver, brain, adipose tissueAlzheimer's disease[25, 54]
SLC30A7/ZnT7Golgi apparatusRetina, small intestine, liver, blood, epithelial cells, spleenProstate cancer[89, 90]
SLC30A8/ZnT8Secretory vesiclesPancreatic B-cellsType 1 and 2 diabetes mellitus[57, 91, 92]
SLC30A9/ZnT9Cytoplasm, nucleusUbiquitously expressedUnknown[93]
SLC30A10/ZnT10UnknownLiver, brainParkinson's disease, dystonia, liver disease[94–96]
MT1Cytoplasm, nucleus, mitochondriaUbiquitously expressedUnknown[97, 98]
MT2Cytoplasm, nucleus, mitochondriaUbiquitously expressedUnknown[99, 100]
MT3Cytoplasm, nucleusBrain, testisAlzheimer's disease[101]
MT4Cytoplasm, nucleusSquamous epitheliaUnknown[102, 103]