Evaluation of the Anti-Inflammatory Effect of Locally Delivered Vitamin C in the Treatment of Persistent Gingival Inflammation: Clinical and Histopathological Study

Figure 5

(a) Photomicrograph of chronically inflamed gingival tissue (preoperative) showing hyperplastic epithelium with long and broad rete ridges and intense inflammatory cell infiltrate in superficial and deep CT (×100). Intraepithelial edema and intense inflammatory cell infiltrate formed of acute and chronic inflammatory cells (×400). (b) Photomicrograph of the same case after single injection of vit-C showing hyperplastic epithelium with slightly narrower rete ridges, numerous minute blood capillaries, collagen fibers formation, and mild inflammatory cell infiltrate (×100). Reduced intercellular edema with fewer chronic inflammatory cells and collagen fibers formation were detected (×400). (c) Photomicrograph of the same case after two injections (in two sessions) of vit-C showing marked reduction in epithelial thickness, superficial minute, and deep larger blood capillaries, collagen fiber bundles formation, and mild inflammatory cell infiltrate (×100). Marked reduction of vacuolized epithelial cells, reduced intercellular edema, well-demarcated basement membrane, increased number of blood capillaries, and almost absence of inflammatory cells (×400).

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