Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity

Table 1

Mitochondrial enzymes in tissues of C57BL/6J (B6) and B6.A-(rs3676616-D10Utsw1)/KjnB6 (B6.A) mice.

		Males		Females
		B6	B6.A	B6	B6.A
CS	H	1834.6 ± 402.3	1063.6 ± 281.5	1736.4 ± 338.7	963.4 ± 205.9
	M^#	750.9 ± 129.9	515.7 ± 96.0	644.7 ± 115.7	417.1 ± 113.0
HAD	H	151.7 ± 43.6	131.1 ± 28.6	137.7 ± 36.4	140.3 ± 21.7
	M^#	12.7 ± 4.0	10.1 ± 2.6	8.4 ± 1.7	9.0 ± 3.7

Citrate synthase (CS) and β hydroxyacyl CoA dehydrogenase (HAD) activity (μmol/min/g protein) in the gastrocnemius muscle (M) and heart (H) of mice was assessed using spectrophotometric assays for tissue homogenates after 12 weeks of high fat diet feeding. The values are means ± SD ( each). B6 vs B6.A strains; ; ^#males vs. females .