Dietary Vitamin C and Age-Induced Lipid and Hormonal Metabolic Changes in a Humanized Mouse Model Not Synthesizing Vitamin C and Producing Lipoprotein(a) [Gulo (−/−); Lp(a)+]

Figure 2

Serum levels of testosterone in H-VC male mice (a) and L-VC male mice (b), estradiol in female mice (c), free IGF-1 (d) in each age group and gender, and correlation between serum free IGF-1 and LDL (e). Data are expressed as mean ± SD. n = 3–6 mice per group. For Tukey’s HSD tests, represents statistically significant difference between H-VC groups and L-VC groups of the same age and gender at the significance level of 0.05; represents statistically significant difference between all three age groups of the same gender and diet at the significance level of 0.01.

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