Clinical Efficacy of Curcumin and Vitamin E on Inflammatory-Oxidative Stress Biomarkers and Primary Symptoms of Menopause in Healthy Postmenopausal Women: A Triple-Blind Randomized Controlled Trial
Table 3
The score of menopause symptoms among the study groups.
Menopause symptoms
Curcumin (n = 26)
Vitamin E (n = 27)
Placebo (n = 28)
value
Anxiety (0–18)
Baseline†
6.4 (2.6)
6.9 (2.3)
6.4 (1.9)
0.680
After 8 weeks†
5.7 (2.6)
5.1 (2.4)
5.8 (1.8)
0.021
MD (95% CI)
−0.8 (−1.5 to −0.01)
−1.8 (−2.5 to −1.2)
−0.6 (−1.1 to −0.1)
value
0.046
<0.001
0.032
Depression (0–15)
Baseline†
6.2 (2.8)
5.0 (2.3)
5.1 (3.0)
0.084
After 8 weeks†
4.7 (2.9)
3.6 (2.4)
3.7 (2.5)
0.923
MD (95% CI)
−1.5 (−2.5 to −0.5)
−1.4 (−2.0 to −0.8)
−1.4 (−2.0 to −0.94)
value
0.006
0.001
<0.001
Psychological (0–33)
Baseline†
12.6 (4.7)
11.9 (3.6)
11.5 (4.3)
0.455
After 8 weeks†
10.4 (4.9)
8.6 (3.9)
9.4 (3.9)
0.058
MD (95% CI)
−2.3 (−3.9 to −0.6)
−3.2 (−4.2 to −2.3)
−2.0 (−2.8 to −1.2)
value
0.001
<0.001
<0.001
Physical (0–21)
Baseline†
5.2 (1.5)
5.6 (1.9)
5.2 (1.9)
0.358
After 8 weeks†
4.1 (1.82)
3.9 (1.3)
4.2 (2.1)
0.107
MD (95% CI)
−1.1 (−1.8 to −0.4)
−1.7 (−2.5 to −0.8)
−1. 0 (−1.5 to −0.5)
value
<0.001
>0.001
0.001
Vasomotor (0–6)
Baseline†
4.4 (1.0)
4.0 (1.9)
4.7 (1.1)
0.746
After 8 weeks†
2.9 (1.6)
2.1 (1.7)
2.8 (1.7)
0.551
MD (95% CI)
−1.5 (−2.2 to −0.8)
−1.8 (−2.6 to −1.1)
−1.9 (−2. 4 to −1.4)
value
<0.001
<0.001
<0.001
Sexual (0–3)
Baseline†
1.4 (0.9)
1.9 (0.8)
1.2 (0.9)
0.467
After 8 weeks†
1.4 (0.9)
1.7 (1.0)
1.1 (0.9)
0.737
MD (95% CI)
0.0 (−0.4 to 0.4)
−0.3 (−0.6 to 0.1)
−0.05 (−0.15 to 0.05)
value
1.00
0.135
0.330
Total score (0–63)
Baseline†
23.6 (5.9)
23.4 (3.6)
22.5 (4.6)
0.949
After 8 weeks†
18.8 (7.2)
16.4 (5.1)
17.5 (5.0)
0.048
MD (95% CI)
−4.8 (−7.4 to −2.1)
−7.0 (−8.8 to −5.2)
−5.0 (−6.5 to −3.5)
value
0.001
<0.001
<0.001
MD: mean difference, CI: confidence interval; †Mean (SD); one-way ANOVA, analysis of covariance adjusted for baseline measures and confounding factors (vitamin C intake), paired-samples t-test.
