Western Diet Decreases Hepatic Drug Metabolism in Male LDLr^−/−ApoB^100/100 Mice

Figure 1

Prolonged Western diet (WD) induces hepatic steatosis in male LDLr^−/−ApoB^100/100 mice. LDLr^−/−ApoB^100/100 male mice were fed the WD for 5 months. When detecting hepatic steatosis, liver sections were stained with hematoxylin-eosin (a) on a chow diet and (b) after 5 months on the WD. When determining liver fibrosis, liver sections (c) on a chow and (d) after the WD was stained with Masson trichrome stain that designates fibrosis with blue color (arrow). The WD induced high increase in hepatic lipid accumulation and infiltration of inflammatory cells (arrowhead) and promoted liver fibrosis. Representative pictures of livers are shown with a scale bar 200 μm.

(a)

(b)

(c)

(d)