Journal of Oncology / 2008 / Article / Tab 2 / Research Article
Radiation Therapy in Addition to Gross Total Resection of Retroperitoneal Sarcoma Results in Prolonged Survival: Results from a Single Institutional Study Table 2 Patient, tumor, and treatment characteristics.
Parameters Preoperative EBRT group
Postoperative EBRT group
P value Gender Female 12 (63%) 8 (67%) 1.00 Male 7 (37%) 4 (33%) Age at presentation ≤50 years 8 (42%) 2 (17%) .24 >50 years 11 (58%) 10 (83%) AJCC stage I 5 (26%) 5 (42%) .24 III 12 (63%) 3 (25%) IV 2 (11%) 2 (17%) Grade 1 3 (16%) 3 (25%) .66 2 4 (21%) 2 (17%) 3 12 (63%) 5 (42%) Tumor size
10 cm7 (37%) 9 (75%) .07
10 cm12 (63%) 3 (25%) Lesion presentation Primary 17 (89%) 7 (58%) .08 Recurrent 2 (11%) 5 (42%) Histology Leiomyosarcoma 9 (47%) 6 (50%) .72 Liposarcoma 7 (37%) 3 (25%) Other 3 (16%) 3 (25%) Extent resection STR 4 (21%) 1 (8%) .62 GTR 15 (79%) 11 (92%) Organs removed No 9 (47%) 3 (25%) .27 Yes 10 (53%) 9 (75%) Chemo No 16 (84%) 9 (75%) .65 Yes 3 (16%) 3 (25%) IORT No 6 (32%) 9 (75%) .03 Yes (1 pt each arm
had 2 fields) 13 (68%) 3 (25%) Radiotherapy dose EBRT median (range) 59.4 Gy (36.8–63.4 Gy) 59.4 Gy (54–68.4) .79 IORT median (range) 11 Gy (10–12 Gy) 11 Gy (10–12 Gy) IMRT No 17 (89%) 4 (33%) .002 Yes 2 (11%) 8 (67%) Time to complete EBRT
Median (range) 45 days
(17–90 days) 44 days
(41–55 days) .76 Length of F/U
Median (range) 22 months
(0.6–56.5 months) 13.05 months
(1.4–66.4 months) .55
EBRT = external beam radiation therapy; STR = subtotal resection; GTR = gross total
resection; IORT = intraoperative radiation therapy; IMRT = intensity modulated
radiation therapy; F/U = follow-up.