New Pathways for Alimentary Mucositis

Table 2

The top 14 cellular and regulatory pathways deemed to be most relevant to mucosal injury from anticancer therapy.

Rank	Chemoradiation (Sonis, etal.)	Irinotecan (Bowen, etal.)
1	Toll-like receptor signalling	MAPK signalling
2	NF-kB signalling	Cell cycle
3	B-cell receptor signalling	Complement and coagulation cascades
4	PI3K/AKT signalling	Gap junction
5	Cell cycle	Calcium signalling
6	P38 MAPK signalling	Apoptosis
7	Wnt/B-catenin signalling	Leukocyte transendothelium migration
8	Glutamate receptor signalling	VEGF signalling
9	Integrin signalling	Cytokine-cytokine receptor interaction
10	VEGF signalling	Neuroactive ligand-receptor interaction
11	IL-6 signalling	Wnt signalling
12	Death receptor signalling	B cell receptor signalling
13	SAPK/JNK signalling	T cell receptor signalling
14	T-cell receptor signalling	Focal adhesion