Analysis of Candidate Genes in Occurrence and Growth of Colorectal Adenomas

Table 4

Effect of combinations of gene polymorphisms in colorectal adenomas.

(a) P-values of combinations of polymorphisms withthin single genes.

Genes	Haplotypic tests			Genotypic tests
	PA versus PF	LA versus PF	LA versus SA	PA versus PF	LA versus PF	LA versus SA
TGFBR2	0.83	0.52	0.45	0.38	0.16	0.22
MLH1	0.64	0.41	0.63	0.45	0.24	0.13
MSH2	0.69	0.21	0.46	0.32	0.17	0.91
TP53	0.42	0.28	0.19	0.49	0.28	0.30
AXIN2	0.49	0.21	0.46	0.84	0.61	0.61
BAX	0.97	0.81	0.87	0.94	0.44	0.88
CTNNB1	0.43	0.16	0.37	0.79	0.43	0.76
MDR1	0.72	0.52	0.51	0.531	0.06	0.38
APC	0.16	0.26	0.014	0.19	0.45	0.08
CARD15	0.61	0.28	0.40	0.67	0.27	0.41
TS	0.63	0.21	0.75	0.60	0.43	0.59

(b) P-values of combinations of polymorphisms in different genes.

Genes groups	Haplotypic tests			Genotypic tests
	PA versus PF	LA versus PF	LA versus SA	PA versus PF	LA versus PF	LA versus SA
APC-MYH	0.20	0.47	0.045	0.42	0.63	0.15
CNNB1-HRAS	0.47	0.25	0.58	0.74	0.31	0.58
MDR1-TP53	0.55	0.51	0.43	0.49	0.24	0.39
AXIN2-APC	0.36	0.19	0.07	0.19	0.73	0.40
TP53-BAX-
TGFBR2-APC	0.19	0.42	0.26	0.64	0.52	0.67
TS-MLH1-
MSH2-MYH	0.97	0.38	0.83	0.68	0.17	0.82