Thrombospondin-1 (TSP-1) Stimulates Expression of Integrin 6 in Human Breast Carcinoma Cells: A Downstream Modulator of TSP-1-Induced Cellular Adhesion
Figure 6
High endogenous TSP-1 production increases cell adhesion to laminin. Stably transfected MDA-MB-435 cells were either incubated alone (a), with either 10 g/mL control IgG or 10 g/mL goat antihuman TSP-1 IgG (b), or either 10 g/mL control IgG or 10 g/mL rat antihuman 6 integrin IgG (c), and assessed for adhesion to laminin as described in Section 2. BSA was used as a negative control. The error bars represent the standard error of the mean of triplicate samples and the experiment was repeated three times with similar results.
