Metabolomic Characterization of Ovarian Epithelial Carcinomas by HRMAS-NMR Spectroscopy

Figure 2

Score plot of the first two principal components (PC1, PC2) from PLS-DA model obtained when comparing: (a) Healthy ovarian tissues (filled triangle) versus the 3 epithelial carcinomas: mucinous (open diamond), endometrioid (open square) and serous (open triangle). Model parameters: 𝑅²𝑌=0.75,𝑄²=0.50. (b) Healthy ovarian tissues (full triangle) versus endometrioid carcinomas (open square). Model parameters: 𝑅²𝑌=0.96,𝑄²=0.45. (c) Healthy ovarian tissues (full triangle) versus mucinous carcinomas (open diamond). Model parameters: 𝑅²𝑌=0.94,𝑄²=0.69. (d) Healthy ovarian tissues (full triangle) versus high Silverberg score (grade III) of serous carcinomas (open triangle). Model parameters: 𝑅²𝑌=0.91,𝑄²=0.68. In these models, the predicted borderline cases are represented by filled circles (c, d) and the predicted low Silverberg score (grade I-II) serous carcinomas by open circles (d).

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