Toll-Like Receptor 7 Agonist Therapy with Imidazoquinoline Enhances Cancer Cell Death and Increases Lymphocytic Infiltration and Proinflammatory Cytokine Production in Established Tumors of a Renal Cell Carcinoma Mouse Model

Figure 7

3M011 increases proinflammatory cytokine production in mouse RCC tumors but not in mouse serum. (a)–(d) Levels of intratumoral IL-6 (a), (b) and MCP-1 (c), (d) cytokines in mouse RCC xenografts on day 9 following treatment with placebo versus 3M011 imidazoquinoline on day 0 and day 7. (e), (f) Levels of serum MCP-1 in mice at the same time points. (b), (d), and (f) Compare mice receiving placebo on both day 0 and day 7 versus mice receiving 3M011 on one or both of these days. *𝑃<0.05, **𝑃<0.01, ***𝑃<0.005, and ^†*𝑃=0.08, ^†𝑃>0.10. Error bars = standard error of the mean.

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