Overexpression of S6 Kinase 1 in Brain Tumours Is Associated with Induction of Hypoxia-Responsive Genes and Predicts Patients' Survival

Table 2

Hypoxia induced genes are overexpressed in human brain tumours.

Gene	Brain tumour type	Upregulation fold/normal	P Value	Patients’ number	Study/year [REF]
SOX4	Oligodendroglioma	27.195	𝑃=7.16𝐸−22	50	Nutt Brain/2006 [36]
	Anaplastic astrocytoma	22.784	𝑃=1.96𝐸−13	19
	Glioblastoma	4.149	𝑃=1.06𝐸−21	81
	Diffuse astrocytoma	9.109	𝑃=0.007	7
	Glioblastoma	3.084	𝑃=8.51𝐸−8	27	Shai Brain/2003 [37]
	Astrocytoma	6.100	𝑃=1.65𝐸−5	45	Rickman Brain/2001 [38]
	Anaplastic oligoastrocytoma	17.598	𝑃=6.05𝐸−5	4	French Brain/2005 [27]
	Anaplastic oligodendroglioma	2.790	𝑃=4.62𝐸−8	23
	Glioblastoma	6.140	𝑃=2.76𝐸−9	27	Bredel Brain 2/2005 [39]
	Oligodendroglioma	12.935	𝑃=2.22𝐸−4	5
	Anaplastic oligodendroglioma	15.078	𝑃=0.002	3
	Anaplastic oligoastrocytoma	8.939	𝑃=0.006	6
	Glioblastoma	4.579	𝑃=2.20𝐸−4	29	Liang Brain/2005 [40]
	Oligoastrocytoma	7.482	𝑃=0.009	3
	Pilocytic astrocytoma	3.445	𝑃=0.008	8	Gutmann Brain/2002 [41]
SOX9	Malignant glioma	4.330	𝑃=9.30𝐸−6	10	Pomeroy Brain/2002 [28]
	Atypical teratoid/rhabdoid tumour	3.668	𝑃=0.007	5
	Desmoplastic medulloblastoma	2.599	𝑃=0.002	14
	Anaplastic oligoastrocytoma	4.005	𝑃=0.009	23	French Brain/2005 [27]
	Anaplastic oligodendroglioma	2.731	𝑃=3.03𝐸−4	4
	Glioblastoma	2.566	𝑃=2.84𝐸−5	27	Shai Brain/2003 [37]
	Anaplastic astrocytoma	2.340	𝑃=2.79𝐸−7	19	Sun Brain/2006 [36]
	Glioblastoma	2.24	𝑃=10𝐸−15	81
VEGFA	Malignant glioma, NOS	210.500	𝑃=0.005	10	Pomeroy Brain/2002 [28]
	Glioblastoma	9.415	𝑃=1.03𝐸−6	26	Bredel Brain 2/2005 [39]
	Glioblastoma	8.624	𝑃=1.51𝐸−19	81	Sun Brain/2006 [36]
	Anaplastic astrocytoma	2.008	𝑃=0.003	19
	Pilocytic astrocytoma	7.651	𝑃=0.001	8	Guttman
	Glioblastoma	5.228	𝑃=5.10𝐸−4	30	Liang Brain/2005 [40]
	Glioblastoma	4.998	𝑃=5.28𝐸−8	27	Shai Brain/2003 [37]
	Anaplastic oligoastrocytoma	4.438	𝑃=0.003	23	French Brain/2005 [27]
	Anaplastic oligodendroglioma	3.121	𝑃=7.92𝐸−6	4
MMP2	Glioblastoma	6.426	𝑃=5.41𝐸−4	27	Bredel Brain 2/2005 [39]
	Glioblastoma	4.537	𝑃=0.003	30	Liang Brain/2005 [40]
	Pilocytic astrocytoma	4.030	𝑃=0.001	8	Gutmann Brain/2002 [41]
	Glioblastoma	3.548	𝑃=7.99𝐸−16	81	Sun Brain/2006 [36]
	Diffuse astrocytoma	3.342	𝑃=0.010	19
	Anaplastic astrocytoma	2.697	𝑃=1.33𝐸−5	7
	Anaplastic oligodendroglioma	2.980	𝑃=1.29𝐸−7	23	French Brain/2005 [27]
	Anaplastic oligoastrocytom	2.214	𝑃=0.006	4
NEDD9	Atypical teratoid/rhabdoid tumour	58.972	𝑃=0.008	5	Pomeroy Brain/2002 [28]
	Malignant glioma, NOS	17.133	𝑃=0.007	10
	Classic medulloblastoma	7.818	𝑃=3.59𝐸−8	46
	Desmoplastic medulloblastoma	5.238	𝑃=0.003	14
	Glioblastoma	2.330	𝑃=3.69𝐸−7	25	Bredel Brain 2/2005 [39]
HIF1A	Oligodendroglioma	3.395	𝑃=0.007	3	Shai Brain/2003 [37]
	Glioblastoma	2.660	𝑃=1.96𝐸−10	27
	Anaplastic oligoastrocytoma	3.101	𝑃=9.50𝐸−4	4	French Brain/2005 [27]
	Anaplastic oligodendroglioma	2.576	𝑃=4.35𝐸−6	23
	Glioblastoma	2.954	𝑃=5.21𝐸−9	26	Bredel Brain 2/2005 [39]
	Anaplastic oligodendroglioma	2.404	𝑃=4.78𝐸−4	3
	Oligodendroglioma	2.167	𝑃=0.003	5
	Diffuse astrocytoma	2.115	𝑃=6.68𝐸−5	7	Sun Brain/2006 [36]
	Astrocytoma	2.057	𝑃=5.79𝐸−4	45	Rickman Brain/2001 [38]