Genetic and Clinical Features of Multiple Endocrine Neoplasia Types 1 and 2

Table 4

Different prevalence of RET germline mutations in hereditary MTC in different European countries.

RET mutation	Italy (𝑛=246) [14]	Germany (𝑛=141) [15]	Euromen (𝑛=145) [16]
Cys634	86 (34.9%)	57 (40%)	98 (67.6%)
Val804	52 (21.1%)	9 (6.4%)	3 (2.1%)
Ser891	23 (9.3%)	3 (2.2%)	3 (2.1%)
Met918	20 (8.1%)	21 (15%)	4 (2.8%)
Cys618	15 (6.0%)	7 (5%)	10 (6.9%)
Glu768	9 (3.6%)	2 (1.4%)	1 (0.8%)
Cys620	9 (3.6%)	10 (7%)	10 (6.9%)
Leu790	8 (3.2%)	17 (12%)	7 (4.8%)
Cys609	6 (2.4%)	1 (0.7%)	1 (0.8%)
Cys630	4 (1.6%)	1 (0.7%)	1 (0.8%)
Cys611	1 (0.4%)	2 (1.4%)	4 (2.8%)
Tyr791	1 (0.4%)	10 (7%)	3 (2.1%)
Ala883	1 (0.4%)	0	0
Cys515	1 (0.4%)	0	0
Lys666	1 (0.4%)	0	0
Met848	1 (0.4%)	0	0
Ser904	1 (0.4%)	0	0
Thr338	1 (0.4%)	0	0
Asp631	0	1 (0.7%)	0
No mutations	6 (2.4%)	0	0