Genetic and Clinical Features of Multiple Endocrine Neoplasia Types 1 and 2

Table 6

Drugs used in ongoing clinical trials for the treatment of advanced MTC and other thyroid tumors.

Drug	Molecular target
Axitinib	VEGFR, PDGFR𝛽, C. Kit
Gefitinib	EGFR
Imatinib	VEGFR, RET, BCR-ABL
Motesanib	VEGFR, RET, PDGFR𝛽, C. Kit
Sorafenib	VEGFR, RET, RET/PTC, BRAF, PDGFR𝛽, C. Kit
Sunitinib	VEGFR, RET, RET/PTC, PDGFR𝛽
Vandetanib	VEGFR, RET, RET/PTC, EGFR
XL184	VEGFR, RET, PDGFR𝛽