Proteomics of Uveal Melanoma: A Minireview

Table 2

Protein change in the metastatic UM cell line.

Category/name	Function	Change (𝑥-fold)
Cellular defense
HSP27	Protein stabilisation	++
Apoptosis/degeneration
Cathepsin Z	Lysosomal proteolysis	++
Proliferation
Annexin	Growth factor	++
Migration
Cofilin	Actin turnover	+++
Tropomodulin 3	Actin turnover	++++++
CLIM1	Actin kinase adaptor	++++++
Galectin	Cell to cell interaction	++
β-Hexosaminidase β-subunit	Glycosidasis	++++++
Metabolism
Pyruvate kinase 3	Glycolysis	−
Enolase 1	Glycolysis	−
Nuclear transport
Ran-binding protein 1	RanGAP activity	++
elF5A	Cofactor in nuclear export	++++++
Translation
CRHSP-24	Translation regulating protein	++++++

Adapted from Zuidervaart et al. [37] (+) 0–1.5. (++) 1.5–5. (+++) 5–10. (++++) 10–50. (+++++) 50–100. (++++++) >100-fold increase. Minus depicts a decrease.