ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases

Figure 1

Schematic version of ligand binding for ErbB family. ErbB1 can bind AR, BCT, EGF, TGFα, EPG, and EPR; ErbB3 can bind BCT, EPR, HB-EGF, NRG -1, and NRG-2, while ErbB4 can bind all four NRG [5, 7]. AR, amphiregulin; BCT, betacellulin; EGF, epidermal growth factor; EPG, epigen; EPR, epiregulin; BH-EGF, heparin-binding EGF; TGFα, transforming growth factor alpha; NRG, neuregulin.