ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases

Table 6

Bioavailability of curcumin.

Species	Route	Dose	Plasma/tissue		AUC	Ref
Rat	i.v.	25 mg/kg	Liver	NA	9.06 ± 1.55 min⋅g/mL	[133]
			Heart	NA	3.03 ± 0.85 min⋅g/mL
			Spleen	NA	5.72 ± 1.14 min⋅g/mL
			Lung	NA	8.98 ± 1.82 min⋅g/mL
			Kidney	NA	12.0 ± 0.88 min⋅g/mL
			Brain	NA	4.04 ± 0.22 min⋅g/mL
Rat	Oral	50 mg/kg	Plasma	13.0 ± 5.8 ng/mL	51.1 ± 25 min⋅g/mL	[151]
		300 mg/kg	Plasma	37.4 ± 36.1 ng/mL	134 ± 114 min⋅g/mL
Rat	Oral	1 g/kg	Plasma	258.64 ng/mL	2483.32 h⋅ng/mL	[134]
Human	Oral	30 mg/kg	Plasma	1.8 ± 2.8 ng/mL	4.1 ± 7 h⋅ng/mL	[151]
Human	Oral	10 g	Plasma	50.5 ng/mL	NA	[132]
		12 g	Plasma	57.6 ng/mL	NA

i.v.: intravenous; i.g.: intragastric; , maximum concentration; AUC, area under the curve; NA, not applicable.