Research Article
Risk Factors for Fatal Pulmonary Hemorrhage following Concurrent Chemoradiotherapy in Stage 3B/C Squamous-Cell Lung Carcinoma Patients
Table 3
Uni- and multivariate correlates of fatal pulmonary hemorrhage in patients with tumor cavitation.
| Variable | Patients (N=60) | FPH (N=13) | Univariate P-value | Multivariate P-value |
| Median TS, n (%) | | | | | <5.1 cm | 27 (45.0) | 6 (22.2) | 0.68 | - | ≥5.1 cm | 33 (54.0) | 7 (21.2) | | |
| Median TV, n (%) | | | | | ≤58.9 cm3 | 26 (43.3) | 5 (19.2) | 0.57 | - | >58.9 cm3 | 34 (56.7) | 8 (23.4) | | |
| Median CS, n (%) | | | | | < 2.6 cm | 28 (46.7) | 6 (21.4) | 0.86 | - | ≥ 2.6 cm | 32 (53.3) | 7 (21.9) | | |
| Median CV, n (%) | | | | | < 22.3 cm3 | 27 (45.0) | 5 (18.5) | 0.23 | - | ≥ 22.3 cm3 | 33 (55.0) | 8 (242 | | |
| Median RCS, n (%) | | | | | < 0.46 | 31 (51.7) | 5 (16.1) | 0.09 | - | ≥ 0.46 | 29 (48.3) | 8 (27.6) | | |
| Ito’s RCS group, n (%) | | | | | Minimum (≤0.25) | 10 (16.7) | 0 (0) | 0.006 | 0.008 | Minor (≥0.25 but <0.50) | 21 (35.0) | 4 (19.0) | | | Major (≥0.5) | 29 (48.3) | 9 (31.0) | | |
| RCV group, n (%) | | | | | ≤0.14 | 36 (55.0) | 4 (11.1) | <0.001 | <0.001 | >0.14 | 24 (45.0) | 9 (37.5) | | |
| Hemoptysis, n (%) | | | | | Absent | 22 (36.7) | 3 (13.6) | 0.007 | 0.009 | Present | 38 (63.3) | 10 (26.3) | | |
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Median values were used, as receiver operating characteristic analysis did not reveal significant cut-off. FPH: fatal pulmonary hemorrhage; TS: tumor size; TV: tumor volume; CS: cavitation size; CV: cavitation volume; RCS: relative cavitation size (largest tumor diameter/largest cavitation diameter); RCV: relative cavitation volume (cavitation volume/tumor volume). |