Secretory High-Mobility Group Box 1 Protein Affects Regulatory T Cell Differentiation in Neuroblastoma Microenvironment In Vitro
Table 2
Patient characteristics of 498 pediatric neuroblastomas adopted from the MAQC-III/SEQC study. Data presented as number (%).
MAQC-III/SEQCa
n=498
Age
<18 months
300 (60.2)
≥18 months
198 (39.8)
Gender
Male
287 (57.6)
Female
211 (42.4)
INSS stage
4S
53 (10.6)
1
121 (24.3)
2
78 (15.7)
3
63 (12.7)
4
183 (36.8)
Risk group
High risk
176 (35.3)
MYCN status
Amplification
92 (18.5)
Non-amplification
401 (80.5)
Unknown
5 (1.0)
HMGB1 mRNA expressionb
Upregulation
55 (11.0)
Downregulation
50 (10.0)
No alteration
393 (79.0)
the NCBI GEO database [28], accession GSE49711 dataset [29]. bHMGB1 mRNA expression in NB tumors, where upregulation and downregulation were defined by the z-score >1.25 and <-1.25, respectively. INSS, International Neuroblastoma Staging System.