GASC1 Promotes Stemness of Esophageal Squamous Cell Carcinoma via NOTCH1 Promoter Demethylation

Figure 3

The correlation between GASC1 level and clinical parameters in ESCC patients. GASC1 expression in all ESCC tissues was measured by immunohistochemistry. (a) The expression of GASC1 in peritumor and different grade tumor tissues from ESCC patients was detected. One representative micrograph is shown. Scale bar represents 30 μm. (b) The expression of GASC1 in tumor and peritumor tissues from ESCC patients is presented as a histogram. (c) The expression of GASC1 in different grade tissues (G1, G2+G3) from ESCC patients is presented as a histogram. (d) GASC1 expression in ESCC tissues with positive and negative lymph node metastasis is shown as a histogram. (e) GASC1 expression in different tumor tissues based upon T score (T1+T2, T3+T4) is shown as a histogram. (f) GASC1 expression in ESCC tissues with different clinical parameters analyzed by immunohistochemistry is shown as a histogram with staining score. (g) Kaplan-Meier survival curves for ESCC patients with lower and higher GASC1 expression (immunohistochemistry analysis). Data are represented as means ± SD. = P < 0.05, = P < 0.01, = P < 0.001, and ns = nonsignificant.

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